Background:The severity of the Coronavirus pandemic has led to lockdowns in different countries to reduce the spread of the infection. These lockdown restrictions are likely to be detrimental to mental health and well-being in adolescents. Physical activity can be beneficial for mental health and well-being; however, research has yet to examine associations between adolescent physical activity and mental health and well-being during lockdown.Purpose:Examine the effects of adolescent perceived Coronavirus prevalence and fear on mental health and well-being and investigate the extent (...) to which physical activity can be a protective factor against these concerns.Methods:During United Kingdom lockdown restrictions, 165 participants (100 female, aged 13–19) completed an online questionnaire assessing perceived Coronavirus prevalence and fear, physical activity, and indicators of mental health and well-being (stress, anxiety, depression, fatigue, vitality, and perceived health). Separate hierarchical multiple linear regression analyses (with age, gender, perceived Coronavirus prevalence, and fear entered in step 1, and physical activity in step 2) were run to predict each well-being outcome.Results:Regression analyses indicated that in general, while Coronavirus fear was a negative predictor, physical activity was a positive and stronger predictor of enhanced mental health and well-being outcomes.Conclusion:Findings suggest that physical activity during the Coronavirus pandemic can counteract the negative effects of Coronavirus fear on adolescent mental health and well-being. Therefore, physical activity should be promoted during lockdown to support good mental health and well-being. (shrink)

The relations between reason, motivation and value present problems which, though ancient, remain intractable. If values are objective and rational how can they move us and if they are dependent on our contingent desires how can they be rational? E. J. Bond makes a bold attack on this dilemma. The widespread view among philosophers today is that judgements contain an irreducible element of personal commitment. To this Professor Bond proposes an account of values as objective and value judgements as true (...) or false, employing a distinction between grounding and motivating reasons to establish their connection with action. He defines and tests his position against a number of recent theories, providing in the process forceful criticism of Williams, Wiggins, Foot, Narveson and Nagel, among others. A distinctive contribution to the subject, it will stimulate interest and worthwhile debate among philosophers, while also serving as an introduction to this vital topic. (shrink)

The essays are arranged in two sections of ethical topics and a section on philosophy, evolution, and the human sciences that includes the title essay, “Making Sense of Humanity.” In World, Mind and Ethics, excellent pieces by Elster, Sen, Jardine, Hookway, McDowell, Nussbaum, Charles Taylor, Altham, and Hollis range even more widely: over ethics, political philosophy, and epistemology, reflecting some of the breadth of Williams’s interests.

Kant gave a two-fold answer to the question, ‘Is existence a predicate?’. His view that existence is not a first-level predicate, i.e., a predicate of objects like horses, stones, and you and me, is widely known. What is not so well-known, however, is his claim that existence is a second-level predicate, a predicate of concepts or of a collection of predicates. In this paper I hope to show why his arguments for both claims are unsuccessful.

Answering important public health questions often requires collection of sensitive information about individuals. For example, our understanding of how HIV is transmitted and how to prevent it only came about with people's willingness to share information about their sexual and drug-using behaviors. Given the scientific need for sensitive, personal information, researchers have a corresponding ethical and legal obligation to maintain the confidentiality of data they collect and typically promise in consent forms to restrict access to it and not to publish (...) identifying data.The interests of others, however, can threaten researchers' promises of confidentiality when legal demands are made to access research data. In some cases, the subject of the litigation is tightly connected to the research questions, and litigants' interest in the data is not surprising. Researchers conducting studies on tobacco or occupational or other chemical exposures, for example, are relatively frequent targets of subpoenas. (shrink)

Prioritizing friendship is associated with many health and well-being benefits. However, to date, there have been relatively few studies that have examined cultural moderators of the link between friendship and important outcomes. In other words, is prioritizing friendships more beneficial in some contexts than others? In the current study, we examined how culture- and country-level factors were associated with the importance people place on friendships and the benefits derived from this importance. The sample comprised of 323,200 participants from 99 countries (...) from the World Values Survey. Multilevel analyses revealed that women, people with higher levels of education, and people living in countries that are more economically equal and high in indulgence placed more value on friendships. Prioritizing friendships in life was associated with better health and well-being, but these associations depended on many cultural factors. The findings are discussed in the context of the ways in which friendships can enrich health and well-being across different settings. (shrink)

The thymus is a unique primary lymphoid organ that supports the production of self‐tolerant T‐cells essential for adaptive immunity. Intrathymic microenvironments are microanatomically compartmentalised, forming defined cortical, and medullary regions each differentially supporting critical aspects of thymus‐dependent T‐cell maturation. Importantly, the specific functional properties of thymic cortical and medullary compartments are defined by highly specialised thymic epithelial cells (TEC). For example, in the medulla heterogenous medullary TEC (mTEC) contribute to the enforcement of central tolerance by supporting deletion of autoreactive T‐cell (...) clones, thereby counterbalancing the potential for random T‐cell receptor generation to contribute to autoimmune disease. Recent advances have further shed light on the pathways and mechanisms that control heterogeneous mTEC development and how differential mTEC functionality contributes to control self‐tolerant T‐cell development. Here we discuss recent findings in relation to mTEC development and highlight examples of how mTEC diversity contribute to thymus medulla function. (shrink)

In his long-awaited Mystic Union , Nelson Pike offers a phenomenology of mysticism. His account is based on the reports and descriptions of third parties, not on his own, first-person experience. So he calls his enterprise ‘phenomenography’, an attempt to describe the experiential content of conscious states by way of reports of them. Pike finds in the Christian mystical tradition three different kinds of experiences of mystic union, the ‘prayer of quiet’, the ‘prayer of union’ and ‘rapture’. These experiences differ (...) phenomenologically, i.e. in experiential content. But they are all ‘theistic’ experiences; that is, they are all phenomenologically of God. By this Pike means: whether these experiences are veridical or not, their object – what they are veridical or hallucinatory experiences of – is God; and that they are of God is part of, or given in, the phenomenological content of the experiences themselves. (shrink)

Until recently, retention of introns in mature mRNAs has been regarded as a consequence of mis‐splicing. Intron‐retaining transcripts are thought to be non‐functional because they are readily degraded by nonsense‐mediated decay. However, recent advances in next‐generation sequencing technologies have enabled the detection of numerous transcripts that retain introns. As we review herein, intron‐retaining mRNAs play an essential conserved role in normal physiology and an emergent role in diverse diseases. Intron retention should no longer be overlooked as a key mechanism that (...) independently reduces gene expression in normal biology. Exploring its contribution to the development and/or maintenance of diseases is of increasing importance. (shrink)

Efforts aimed at broadening participation in science, technology, engineering, and mathematics (STEM) require a holistic presentation of the state of racial and gender participation. Statistics currently used to describe participation often include raw counts of degrees and the percentages of demographic groups receiving STEM degrees. While these data provide insights into demographic trends, they do not present the complete picture because these “traditional” statistics do not capture how well a field of study reflects—or is proportionally similar to—a larger body, such (...) as the college population. If the goal of broadening participation in STEM education is to ensure that all racial and gender groups are proportionally represented, analysts require direct measures of representation. In this article, we present a novel metric that assesses the degree to which groups are overrepresented or underrepresented in a given field. This metric calculates field-specific representation by comparing the proportion of degrees awarded to members of a demographic group in a specific field of study with the proportion of all degrees awarded to that group. Using data from the National Science Foundation and the Department of Education, we demonstrate the efficacy of this representation metric and show that it provides new insights into STEM participation levels for women and other groups considered to be underrepresented. While traditional measurements show the increasing number of degrees awarded to and the increasing share of underrepresented minority students in STEM, our metric revealed that underrepresented minorities remain underrepresented in STEM fields, especially in engineering and the natural sciences. (shrink)

Williams claims that the only particular moral truths, and perhaps the only moral truths of any kind, are nonobjective, i.e., culture-bound. For Lovibond we have moral truths when an assertion-condition is satisfied, and that is determined by the voice of the relevant moral authority as embodied in the institutions of the sittlich morality. According to MacIntyre one must speak from within a living tradition for which there can be no external rational grounding. However, if my criticisms of traditional philosophical (...) ethics are sound, such relativist and historicist views are unjustified, and the project of seeking a rationally grounded morality is perfectly in order. (shrink)

The fourteenth-century English philosopher and theologian Richard Kilvington presents a useful correction to popular views of medieval philosophy in two ways. On the one hand, he reminds us that to think of medieval philosophy in terms of Aquinas, Duns Scotus and Ockham, or to think of medieval logic in terms of Aristotelian syllogistic, is to overlook vast areas of intellectual endeavour. Kilvington, like many before and after him, was deeply concerned with problems that would now be assigned to philosophy of (...) language; philosophical logic and philosophy of science. He discussed topics in epistemic logic, semantic paradoxes, problems of reference, particularly those connected with the interplay between quantifiers and modal or temporal operators, and problems arising from the use of infinite series in the analysis of motion and change. On the other hand, this very account of his work raises the important issue of conceptual domain. I have spoken as if Kilvington's work can be neatly classified in terms of contemporary interests; and the temptation to read medieval philosophy in modern terms is only strengthened when one recognizes Kilvington as the first member of the group of Oxford calculatores, men such as William Heytesbury and Richard Swineshead, whose discussions of mathematics and physics have caused them to be hailed as forerunners of modern science. (shrink)

Different authors offer subtly different characterizations of naïve realism. We disentangle the main ones and argue that illusions provide the best proving ground for naïve realism and its main rival, representationalism. According to naïve realism, illusions never involve per- ceptual error. We assess two leading attempts to explain apparent perceptual error away, from William Fish and Bill Brewer, and conclude that they fail. Another lead- ing attempt is assessed in a companion paper, which also sketches an alternative representational account.

Background: The factors influencing parents’ willingness to enroll their children in biobanks are poorly understood. This study sought to assess parents’ willingness to enroll their children, and their perceived benefits, concerns, and information needs under different consent and data-sharing scenarios, and to identify factors associated with willingness. Methods: This large, experimental survey of patients at the 11 eMERGE Network sites used a disproportionate stratified sampling scheme to enrich the sample with historically underrepresented groups. Participants were randomized to receive one of (...) three consent and data-sharing scenarios. Results: In total, 90,000 surveys were mailed and 13,000 individuals responded (15.8% response rate). 5737 respondents were parents of minor children. Overall, 55% (95% confidence interval 50–59%) of parents were willing to enroll their youngest minor child in a hypothetical biobank; willingness did not differ between consent and data-sharing scenarios. Lower educational attainment, higher religiosity, lower trust, worries about privacy, and attitudes about benefits, concerns, and information needs were independently associated with less willingness to allow their child to participate. Of parents who were willing to participate themselves, 25% were not willing to allow their child to participate. Being willing to participate but not willing to allow one’s child to participate was independently associated with multiple factors, including race, lower educational attainment, lower annual household income, public health care insurance, and higher religiosity. Conclusions: Fifty-five percent of parents were willing to allow their youngest minor child to participate in a hypothetical biobank. Building trust, protecting privacy, and addressing attitudes may increase enrollment and diversity in pediatric biobanks. (shrink)